Unlike other IP agreements, TRIPS have an effective enforcement mechanism. States can be disciplined by the WTO dispute settlement mechanism. Article 63.2 of the ON TRIPS agreement stipulates that members must disclose laws and regulations relating to the purpose of the agreement (availability, scope, acquisition, enforcement and prevention of abuse of intellectual property rights). Since the TRIPS agreement came into force, it has been criticized by developing countries, scientists and non-governmental organizations. While some of this criticism is generally opposed to the WTO, many proponents of trade liberalization also view TRIPS policy as a bad policy. The effects of the concentration of WEALTH of TRIPS (money from people in developing countries for copyright and patent holders in industrialized countries) and the imposition of artificial shortages on citizens of countries that would otherwise have had weaker intellectual property laws are common bases for such criticisms. Other critics have focused on the inability of trips trips to accelerate the flow of investment and technology to low-income countries, a benefit that WTO members achieved prior to the creation of the agreement. The World Bank`s statements indicate that TRIPS have clearly not accelerated investment in low-income countries, whereas they may have done so for middle-income countries.  As part of TRIPS, long periods of patent validity were examined to determine the excessive slowdown in generic drug entry and competition. In particular, the illegality of preclinical testing or the presentation of samples to be authorized until a patent expires have been accused of encouraging the growth of certain multinationals and not producers in developing countries. Article 69 of the agreement requires members to establish and inform points of contact in their administrations in order to cooperate in order to eliminate trade in goods that were enforcement.
The TRIPS agreement is part of the only obligation arising from the Uruguay Round negotiations. This means that the TRIPS agreement applies to all WTO members. It also means that the provisions of the agreement are subject to the WTO`s integrated dispute settlement mechanism, which is contained in the Dispute Settlement Rules and Procedures Agreement. However, the agreement stipulates that members must provide for the protection of plant varieties, either through patents or through an effective sui generis system (i.e.: